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Integrating CLARIOstar Microplate Reader with Multi Well Plates
Integrating CLARIOstar Microplate Reader with Multi Well Plates

Describing how users can use Scispot to setup and analyze their multi well plates used with the Clariostar Plate Reader

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Written by Satya Singh
Updated over 4 months ago

Overview

With our Clariostar - Well Plate integration, users can now connect their well plate layouts within Scispot with their Clariostar Microplate Reader. Data measured by the reader can then be automatically sent back to Scispot and sync with the corresponding well plate within the platform! This allows users to keep all of their most important information in the same place, while still being able to make use of their favourite instruments.

TL;DR

Here is the official guide from Clariostar that highlights the details regarding importing and exporting data to and from Clariostar and Scispot

Part 1: Exporting Multi Well Plates to Clariostar Microplate Reader

Step 1: Create a Multi Well Plate

  1. Whether through a protocol template with an embedded manifest template, or through a manifest on its own, create a new manifest for testing with Clariostar

  2. Add your sample data stored in a Labsheet and layout the samples in the manifest as desired

Step 2: Export the Multi Well Plate in Clariostar compatible format

  1. In the top right hand corner of your manifest, under the well plate tab, select Export

  2. Select the desired instrument from the Instruments dropdown

  3. Based on the instrument selection, compatible file types will appear in the Supported File Type dropdown - select the desired file type

  4. Once this information is complete, select Export to download a Clariostar compatible file of the created multi well plate

Step 3: Import the plate into Clariostar

  1. Within the Clariostar control software, navigate to the Start Measurement screen and select a multi well plate that is the same size as the one created within Scispot

  2. Select the Samples IDs / Dilution Factors tab to open the well plate table for the new test

  3. Select Import IDs in the bottom right hand side of the screen and in the resulting file selector, choose the downloaded multi well plate file from Step 2

Step 4: Run your measurement!

  1. The control software on your plate reader will now populate with sample ID values, creating a mirror of your Scispot multi well plate on your Clariostar and completing the setup of your well plate for testing

  2. Ensure that you have setup your Clariostar to save data in ASCII format - help in setting this up can be found here

Part 2: Syncing Results and Multi Well Plates

For an automated live syncing solution of data from the Clariostar plate reader, check out our article on using a Scispot GLUE!

Step 1: Upload data

  1. Within the manifest on Scispot used to create the multi well plate used above, navigate to the Analysis tab

  2. In the top right hand corner of the screen, select Import Columns

  3. Under Source Type, select the Clariostar plate reader instrument

  4. Select Upload file and select the ASCII file from your plate reader corresponding to your test run

  5. Select Import to automatically get the columns of data from your test

Step 2: Import data

  1. Select the columns from the file to be added to the Analysis sheet

  2. Select Add selected columns to add them to the Analysis sheet

Step 3: Analyze data

  1. Now with the data imported into the Analysis sheet, formula columns can be created to help analyze and visualize the resulting data

  2. Data from other existing labsheets can also be imported into the analysis through the Import Columns -> Labsheet flow

  3. Once you bring in your data from Clariostar to your well-plates, you can add calculated columns to it as well, such as calculation for protein concentration

  4. Add a column using the + icon, name it Protein Conc 1:10 (562nm)

  5. Apply your formula. For instance, if you are subtracting a constant from the absorbance, and then dividing it with the gradient

Part 3: Syncing Analysis with Labsheets

Labsheets are your single source of truth so once all the analysis is done, you can bring that data back to your Labsheets

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